I’ve been full time on the Dvorak keyboard since the end of January, and am just now able to type at anything approaching a normal speed — but I get faster every day. I don’t move my hands nearly as much, my wrists don’t hurt, I have to use all of my fingers and — curiously — I type rather well with my eyes closed.
But I was a very frustrating process and as close as experiencing the motor disability of a stroke as I ever hope to have. (That said, there are versions of Dvorak for those with the use of only one hand.)